个人情况综述

      东北农业大学博士，美国亚利桑那州立大学博士后，副教授，博士生导师，国家级青年人才。多年来一直从事新型细菌性口服疫苗及微生态制剂研究，发表学术论文100余篇，其中SCI收录期刊近100篇，以第一作者或通讯作者在J Nanobiotechnology、Appl Environ Microbiol、Microbiology Spectrum、 Infection and Immunity等SCI期刊发表文章22篇，论文他引次数超1000次，研究成果被包括Nature Reviews Microbiology, Plos Pathogens, Journal of Immunity在内的多篇期刊引用报道，其中发表于Avian diseases的论文被评为2015年度5佳论文奖(PP Levine Award)；发表于美国微生物协会经典期刊Appl Environ Microbiol的论文国际上首创了新型CRIM 微环DNA疫苗平台，开辟了微环DNA疫苗在兽用领域应用的新途径，该研究获评当期亮点（Spotlight）研究；受邀在Springer出版社发行的“Methods in Molecular Biology”系列“DNA vaccines”一书中攥写关于微环DNA疫苗最新进展的章节。
      先后主持国家高层次青年人才项目1项、国家自然科学青年基金1项，面上项目2项，国家重点研发计划项目子课题2项，吉林省科技厅自然科学基金面上项目1项，吉林省教育厅十三五科技规划重点项目2项，重大项目1项，吉林农业大学青年拔尖人才基金1项。现担任中国微生物学会兽医微生物学分会青年委员，中国兽医协会团体标准技术委员会家禽疾病诊疗分委会委员。

学习工作简历

教育经历

1999/09-2003/07,  东北农业大学，生命科学理科基地班，本科/学士；

2003/09-2006/07，东北农业大学，预防兽医学，硕士；

2006/09-2009/07，东北农业大学，预防兽医学，博士；

工作经历：

2009/08-2010/01， 哈药集团生物技术有限公司，研发；

2010/03-2014/09，美国亚利桑那州立大学，生物设计研究所，传染病与疫苗中心，博士后；合作导师：美国科学院院士Roy Curtiss III,。

2015/09-至今，吉林农业大学永乐国际/动物医学院。

教学工作

兽医学留学生： 微生物与免疫学

硕士研究生：高级分子生物学、基因工程

本科生：兽医微生物学、动物微生物学、现代生物技术实验

主要科研方向

新功能型微生态制剂研制，主要包括以乳酸菌及减毒沙门氏菌为载体的口服疫苗研究。

主要科研项目

1.国家高层次人才青年项目，2021-2024,120万；
2.国家自然科学基金面上项目“基于“侵入-溶酶体逃逸-延迟裂解”型本源乳酸菌的肉鸡坏死性肠炎疫苗黏膜免疫机制研究”，32373043，50万，2024-2027；
3.国家自然科学基金面上项目“基于新型微环DNA技术平台CRIM的H9N2禽流感广谱性原位靶向纳米疫苗激活特异性细胞免疫机制研究”，32072897，59万，2021-2024；
4.国家自然科学基金青年基金项目“延迟裂解型沙门菌递送新城疫mcDNA疫苗的免疫效应与机制研究，31602092，21万，2017-2019；
5.十四五“国家重点研发计划项目”之“新型替抗微生态制剂创制与产业化关键技术研发”子课题， 2023YFD1800301，60万，2024-2027；
6.十三五“国家重点研发计划项目”之“畜禽重要胞内寄生原虫的寄生与免疫机制研究”子课题， 2017YFD0500400，35万，2017-2020；
7.吉林省教育厅自然科学基金重大项目，基于沙门菌CRIM微环DNA平台及eVLP病毒样颗粒技术的VII型新城疫口服疫苗研究，JJKH20240470KJ，10万，2024-2025；
8.吉林省科技厅自然科学基金面上项目，延迟裂解-侵入型植物乳杆菌递送H9N2亚型禽流感口服纳米疫苗研究，20220101341JC， 2022-2025；
9.吉林省教育厅“十三五”科学技术项目一般项目“新型高效基因VII型新城疫病毒CRIM口服疫苗创制”， JJKH20200358KJ，2.5万，2020-2021；
10.吉林农业大学首批青年拔尖人才支持计划课题, 30万，2016-2018；
11.吉林省教育厅“十三五”科学技术项目重点项目“新功能侵入型乳酸菌疫苗的构建及其分子免疫机制研究”，JJKH20170316KJ ，5万，2017-2018。

主要科研成果

免疫增强型抗感染微生态制剂创制及在健康养殖中的应用，吉林省科学技术奖，一等奖，6/15，2018年11。

发表文章

1.A novel "prime and pull" strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge. Zhannan Wang, Yingkai He, Wenfeng Wang, Yawen Tian, Chongbo Ge, Futing Jia, Tongyu Zhang, Gerui Zhang, Mingyue Wang, Jinshuo Gong, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Yanlong Jiang*, Guilian Yang*, Chunfeng Wang*. J Nanobiotechnology. 2023 Dec 13;21(1):479.
2.Chicken dendritic cell-targeting nanobodies mediated improved protective effects against H9N2 influenza virus challenge in a homologous sequential immunization study. Futing Jia, Chao Sun, Chongbo Ge, Zhannan Wang, Tongyu Zhang, Menglei Zhang, Wenfeng Wang, Yawen Tian, Yingkai He, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Yanlong Jiang*, Chunfeng Wang*.Vet Microbiol. 2023 Oct:285:109875.
3.Homologous Sequential Immunization Using Salmonella Oral Administration Followed by an Intranasal Boost with Ferritin-Based Nanoparticles Enhanced the Humoral Immune Response against H1N1 Influenza Virus. Zhannan Wang, Tongyu Zhang, Futing Jia, Chongbo Ge, Yingkai He, Yawen Tian, Wenfeng Wang, Guilian Yang, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Chunfeng Wang*, Yanlong Jiang*. Microbiol Spectr. 2023 Jun 15;11(3):e0010223.
4.Protective effects of E. coli Nissle 1917 on chickens infected with Salmonella pullorum. Chao Sun, Xingyun Gao, Ming Sun, Zhannan Wang, Ying Wang, Xiaohan Zhao, Futing Jia, Tongyu Zhang, Chongbo Ge, Xiao Zhang, Menglei Zhang, Guilian Yang, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Xin Cao, Nan Wang, Yan Zeng, Chunfeng Wang*, Yanlong Jiang*.Microb Pathog. 2022 Nov:172:105768.
5.Protection against genotype VII Newcastle disease virus challenge by a minicircle DNA vaccine coexpressing F protein and chicken IL-18 adjuvant. Zhannan Wang, Ying Wang, Chao Sun, Xiaohan Zhao, Ming Sun, Xingyun Gao, Futing Jia, Tongyu Zhang, Chongbo Ge, Xiao Zhang, Menglei Zhang, Guilian Yang, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Xin Cao, Nan Wang, Yan Zeng, Chunfeng Wang*, Yanlong Jiang*.Vet Microbiol. 2022 Jul:270:109474.
6.In Vivo Production of HN Protein Increases the Protection Rates of a Minicircle DNA Vaccine against Genotype VII Newcastle Disease Virus，Zhannan Wang, Xiaohan Zhao, Ying Wang, Chao Sun, Ming Sun, Xingyun Gao, Futing Jia, Chenxin Shan, Guilian Yang, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Aidong Qian, Chunfeng Wang*, Yanlong Jiang*. Vaccines (Basel). 2021 Jul 2;9(7):723.
7.Dendritic cells targeting Lactobacillus plantarum strain NC8 with surface  displayed single chain variable fragment of CD11c induce antigen specific protective cellular immune response. Jing Liu, Guilian Yang, Haibin Huang, Chunwei Shi, Xing Gao, Wentao Yang, Zan Zhang, Yang Liu, Ke Xu, Jianzhong Wang, Yuanhuan Kang, Yanlong Jiang*, Chunfeng Wang*. Infection and Immunity, 2020, Feb;88(2): e00759-19. 
8.Yanlong Jiang, Xing Gao, Ke Xu, Jianzhong Wang, Haibin Huang, Chunwei Shi, Wentao Yang, Yuanhuan Kang, Roy Curtiss, Guilian Yang*, Chunfeng Wang*. A novel Cre recombinase-mediated in vivo minicircle DNA (CRIM) vaccine provides partial protection against Newcastle disease virus, Applied and Environmental Microbiology, 2019, Jul 1;85(14). pii: e00407-19. （Spotlight研究）
9.Jing Liu, Guilian Yang, Xing Gao, Zan Zhang, Yang Liu, Qiong Liu, Jean-Marc Chatel, Yanlong Jiang*, Chunfeng Wang*. Recombinant invasive Lactobacillus plantarum expressing Fibronectin Binding Protein A induce specific humoral immune response by stimulating differentiation of dendritic cells. Benef Microbes, 2019,  May 28;10(5):589-604.
10.Xing Gao, Ke Xu, Guilian Yang, Chunwei Shi, Wentao Yang, Jing Liu, Qiong Liu, Jianzhong Wang, Haibin Huang, Yuanhuan Kang, Yanlong Jiang*, Chunfeng Wang*. Construction of a novel DNA vaccine candidate targeting F gene of genotype VII Newcastle disease virus and chicken IL-18 delivered by Salmonella. J App Microbe,  2019, 126(5):1362-1372.
11.Liu J, Yang G, Gao X, Zhang Z, Liu Y, Yang X, Shi C, Liu Q, Jiang Y*, Wang C*. Immunomodulatory properties of Lactobacillus plantarum NC8 expressing an anti-CD11c single-chain Fv fragment, J Microbiol Biotechnol, 2019 ; 29(1): 160~170
12.Wilde S#, Jiang Y#, Tafoya AM, Horsman J, Yousif M, Vazquez LA, Roland KL*. Salmonella-vectored vaccine delivering three Clostridium perfringens antigens protects poultry against necrotic enteritis. PLoS One, 2019 Feb 12;14(2):e0197721.
13.Yanlong Jiang, Guilian Yang, Qi Wang, Zhannan Wang, Wentao Yang, Wei Gu, Chunwei Shi, Jianzhong Wang, Haibin Huang, Chunfeng Wang*. Molecular mechanisms underlying protection against H9N2 influenza virus challenge in mice by recombinant Lactobacillus plantarum with surface displayed HA2-LTB. J Biotechnol, 2017 Oct 10;259:6-14. 
14.Yanlong Jiang, Liping Ye, Yulin Cui, Guilian Yang, Wentao Yang, Jianzhong Wang, Jingtao Hu, Wei Gu, Chunwei Shi, Haibin Huang, Chunfeng Wang*. Effects of Lactobacillus rhamnosus GG on the maturation and differentiation of dendritic cells in rotavirus-infected mice. Benef Microbes，2017 Aug 24;8(4):645-656. 
15.G. Yang#, Y. Jiang#, P. Tong, C. Li, W. Yang, J. Hu, L. Ye, W. Gu, C. Shi, B. Shan, C. Wang*.Alleviation of enterotoxigenic Escherichia coli challenge by recombinant Lactobacillus plantarum expressing a FaeG- and DC-targeting peptide fusion protein. Benef Microbes, 2017, 8(3):379-391
16.Jiang Y#, Yang G#, Meng F, Yang W, Hu J, Ye L1, Shi C, Wang C*. Immunological mechanisms involved in probiotics mediated protection against Citrobacter rodentium induced colitis. Benef Microbes, 2016 Jun;7(3):397-407.
17.Jiang Y#, Hu J#, Guo Y, Yang W, Ye L, Shi C, Liu Y, Yang G, Wang C*. Construction and immunological evaluation of recombinant Lactobacillus plantarum expressing HN of Newcastle disease virus and DC- targeting peptide fusion protein. J Biotechnol, 2015 Dec 20;216:82-9. 
18.Jiang Y, Mo H, Willingham C, Wang S, Park J Y, Kong W, Roland K L, Curtiss R, 3rd*. Protection Against Necrotic Enteritis in Broiler Chickens by Regulated Delayed Lysis Salmonella Vaccines. Avian Diseases, 2015, 59(4): 475-485.
19.Guilian Yang,# Yanlong Jiang,# Wentao Yang, Fang Du, Yunbao Yao, Chunwei Shi, and Chunfeng Wang*. Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microbial Cell Factories, 2015,14:202
20.Yanlong Jiang, Qingke Kong, Kenneth Roland, Roy Curtiss III*. Membrane vesicles of Clostridium perfringens Type A strains induce innate and adaptive immunity. International Journal of Medical Microbiology, 2014, May;304(3-4):431-43
21.Yanlong Jiang, Qingke Kong, Kenneth Roland, Roy Curtiss III*. Multiple inhibition effects of E.coli Nissle strain on Clostridium perfringens. FEMS Pathogens and disease, 2014, Apr;70(3):390-400. 
22.Yanlong Jiang, H. Liu , P. Liu, and X. Kong*. Plasmids driven rescue system for Newcastle disease virus V4 strain. Molecular Biology Reports, 2009,36:1909-1914

教材及专著

Mucosal Vaccines: Innovations for Preventing Infectious Diseases ，第二版，参编， ELSEVIER出版，ISBN: 978-0-12-811924-2，2020, Pages 383-399，章节题目：Attenuated Salmonella for Oral Immunization;

Methods in Molecular Biology丛书，DNA Vaccines: Methods and Protocols，参编，2021;2197:3-12，Springer出版，章节题目：A Novel Cre Recombinase-Mediated In Vivo Minicircle (CRIM) DNA Vaccine Platform for Veterinary Application

获奖信息

国家高层次人才青年项目；吉林农业大学首批青年拔尖人才

社会兼职

中国微生物学会兽医微生物学会青年委员；中国兽医协会团体标准技术委员会家禽疾病诊疗分委会委员。